Cancer cell motility is one of the major events involved in the metastatic process. Tumor cells that disseminate from a primary tumor can migrate into the vascular system and, being carried by the bloodstream, transmigrate across the endothelium, giving rise to a new tumor site. We develop technologies and methods to better understand cell dynamics underlying tumor invasiveness.
In particular, we exploit two-photon lithography in its full potential to create innovative 3D porous structures, e.g. by modulating pore size and materials mechanical properties, which allow to study cell/structure interactions and realize cell sorting tools on the base of their different invasive behaviour.