All Publications
2026
Rifai O.M., Waldron F.M., O'Shaughnessy J., Read F.L., Gilodi M., Pastore A., Shneider N.A., Tartaglia G.G., Zacco E., Spence H., Gregory J.M.
Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis
Brain Communications, vol. 8, (no. 2)
Article
Journal
2026
Milordini G., Zacco E., Masi M., Armaos A., Di Palma F., Oneto M., Gilodi M., Rupert J., Broglia L., Varignani G., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction impair homologous recombination and induce synthetic lethality
Nature Communications, vol. 17, (no. 1)
Article
Journal
2025
Intze A., Temperini M.E., Rupert J., Polito R., Veber A., Puskar L., Schade U., Ortolani M., Zacco E., Tartaglia G.G., Giliberti V.
Effect of RNA on the supramolecular architecture of α-synuclein fibrils
Biophysical Journal
2024
Spence H., Waldron F.M., Saleeb R.S., Brown A.-L., Rifai O.M., Gilodi M., Read F., Roberts K., Milne G., Wilkinson D., O'Shaughnessy J., Pastore A., Fratta P., Shneider N., Tartaglia G.G., Zacco E., Horrocks M.H., Gregory J.M.
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, (no. 1)
2024
Zacco E., Broglia L., Kurihara M., Monti M., Gustincich S., Pastore A., Plath K., Nagakawa S., Cerase A., Sanchez de Groot N., Tartaglia G.G.
RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
Chemical Reviews, vol. 124, (no. 8), pp. 4734-4777
Dissemination
2025
Milordini G., Zacco E., Masi M., Armaos A., Di Palma F., Oneto M., Gilodi M., Rupert J., Broglia L., Varignani G., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
A RNA-based molecule enhances therapies against pancreatic cancer
ecancer
Media
2024
Spence H., Waldron F. M., Saleeb R. S., Brown A. L., Rifai O. M., Gilodi M., Read F., Roberts K., Milne G., Wilkinson D., O Shaughnessy J., Pastore A., Fratta P., Shneider N., Tartaglia G. G., Zacco E., Horrocks M. H., Gregory J.
New tool detects signs of motor neuron disease before symptoms begin
Medical Xpress
Media
2022
Zacco E.
Going out of phase: RNA to explore early events in protein phase separation and phase transition.
Nature webcast series
Media
2022
Zacco E., Kantelberg O., Milanetti E., Armaos A., Panei F.P., Gregory J., Jeacock K., Clarke D.J., Chandran S., Ruocco G., Gustincich S., Horrocks M.H., Pastore A., Tartaglia G.G.
New in-silico-designed protein ‘probes' could pave the way to early diagnosis of neurodegenerative diseases
EurekAlert!
Media
Scientific Talks
2025
Zacco E.
Going out of phase: RNA aptamers to interfere with and detect pathological protein condensation
EMBL Conference: The expanding world of RBPs
Conference
2023
Zacco E.
Aberrant protein and RNA condensation and its role in neurodegeneration: the example of TDP-43 in amyotrophic lateral sclerosis.
Seminars in Neurosciences
School (Summer school, ...)
2022
Zacco E.
Amino acid-glycan conjugates as protein aggregation inhibitors: A spoonful of sugar against proteinopathies
Neuroglycoprotein in health and disease
Workshop/Symposium
2022
Zacco E.
A tale of proteins and RNA in biological condensation
University of Milano-Bicocca
Institute
2022
Zacco E.
Exploring early events in protein aggregation with aptamers.
Physics of Biomolecules
Conference
Awards and Achievements
2025
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment, advancing synthetic lethality in cancer therapy
2025
Zacco E.
National scientific accreditation in Molecular Biology
2024
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment, advancing synthetic lethality in cancer therapy
2023
Zacco E.
National scientific accreditation in Biochemistry
2023
Tartaglia G., Zacco E.
Target ALS grant
Editorships
2021
Zacco E.
Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics
2019
Zacco E.
Protein and RNA Networks and Biology, section of Frontiers in Molecular Biosciences
2018
Zacco E.
Protein Misfolding in Ageing and Neurodegeneration, research topic in Frontienrs in Molecular Bioscience
Organized Events
2018
Zacco E., Pastore A.
Protein misfolding in ageing and neurodegeneration: from basic biology to drug development